Therapeutic effect of probiotics as an adjuvant treatment for major depressive disorder
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Abstract
Introduction: In the field of mental health, factors such as unbalanced diet, infections, and sustained stress lead to alterations in the functions of the intestinal microbiota, including the synthesis of neuroactive compounds. Probiotics are attributed a potential therapeutic effect in pathologies such as major depressive disorder (MDD) by modulating the gut-brain microbiota axis. Objective: To identify probiotic strains that have potential effects on the symptoms of major depressive disorder.. Materials and methods: A descriptive bibliographic review was carried out with information collected from meta-analyses, systematic reviews, randomized controlled studies, bibliographic reviews, intervention studies, pilot studies obtained from specialized databases such as PubMed, ScienceDirect and Cochrane Library published between 2020 and 2024.Conclusions: The effects are specific to each strain. The capacity of Lactobacillus helveticus and Bifidobacterium longum to boost tryptophan along the serotonin pathway, improving mood, anhedonia and sleep quality, is highlighted. Bifidobacterium breve CCFM1025 regulates the serotonergic system and the metabolism of tryptophan, a precursor of serotonin, capable of alleviating the symptoms of MDD. Despite the positive findings around the strains studied, research in larger populations is required to determine the efficacy and safety of probiotic supplementation to the classic treatment of MDD.
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Anabel Estefania Caiza-Bustos , Universidad Técnica de Ambato - Ecuador
https://orcid.org/0009-0006-0019-2542
Rotating Medical Intern at the Latacunga General Hospital.
Medical Student at the Technical University of Ambato
Roberto Iván Acosta-Gavilánez , Sociedad Ecuatoriana de Medicina Familiar / Universidad Técnica de Ambato - Ecuador
https://orcid.org/0000-0002-8162-7600
Medical Specialist in Family and Community Medicine, Master in Gerontology and Person-Centered Care, Diploma in Scientific Research, Diploma in University Teaching. Coordinator of the Quisapincha Type A Health Center. Professor at the Technical University of Ambato.
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