Therapeutics for gait blocking in patients with Parkinson's
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Abstract
Parkinson's disease is a chronic, progressive neurological disorder that primarily affects the motor system, including walking. Gait disturbance is one of the most disabling and debilitating symptoms for Parkinson's patients. The objective is to define Parkinson's disease interventions addressing traditional and non-traditional approaches to improve gait in patients with Parkinson's disease and provide recommendations for clinical practice. A narrative review of the literature and a systematic review of randomized controlled trials (RCTs) were carried out. These reviews summarized Parkinson's disease interventions addressing traditional and non-traditional approaches to improving gait in patients with PD over the past 10 years, all searches were conducted in PubMed and Scopus and study selection was performed independently. . The main results show that gait blockage is a debilitating and common symptom in patients with Parkinson's disease (PD), which significantly limits their mobility and quality of life. Pharmacological approaches are established, such as levodopa, and the juxtaposition of deferiprone that can temporarily improve gait in some patients, and physical therapies, such as physical therapy and deep brain stimulation, are evidenced. It is concluded that neurosurgical, pharmacological or non-pharmacological therapies can be used based on a thorough evaluation of the patient's clinical history, the severity of symptoms and the potential risks and benefits of the intervention.
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Noelia Lisseth Tinoco-Aguilar , Universidad Técnica de Ambato - Ecuador
https://orcid.org/0000-0003-3098-3952
Rotating Medicine Intern at Latacunga General Hospital
Medical student at the Technical University of Ambato
Roberto Iván Acosta-Gavilánez , Sociedad Ecuatoriana de Medicina Familiar - Ecuador
https://orcid.org/0000-0002-8162-7600
Medical Specialist in Family and Community Medicine, Master in Gerontology and Person-Centered Care, Diploma in Scientific Research, Diploma in University Teaching. Coordinator of the Quisapincha Type A Health Center. Professor at the Technical University of Ambato.
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